Papers published in medical journals are most highly cited, as New England Journal of Medicine publishes "Hottest" paper of 2005.

Philadelphia, PA USA-London UK - March 20, 2006 - The New England Journal of Medicine leads the pack in this year’s "Red-Hot Research Papers" rankings by publishing the most-cited research paper of 2005. This, according to the March/April issue of Science Watch—the bimonthly newsletter published by Thomson Scientific, a business unit of The Thomson Corporation.

New England Journal of Medicine (NEJM) boasts this ranking in a year that seems to have been dominated by highly-cited articles in medical publications. Thirteen of the top-40 most-cited papers were published in NEJM, with four of the top-five most-cited articles appearing in its pages.

The research group led by Paul M. Ridker, Harvard University professor of medicine, tops the list of Red-Hot Research Papers for "C-reactive protein levels and outcomes after statin therapy," published in NEJM, January 2005. Ridker is also the only researcher to be listed as the first author on more than one paper—numbers one and 30.

"Our annual roundup of the hottest research papers celebrates researchers whose work influences modern scientific thought," said Christopher King, editor of Science Watch. "It also helps us spot trends and 'hot' fields of study. This year, for example, we see that many of the 'hottest' papers were published in medical publications."

The Red-Hot Research Papers of 2005
(Ordered by total citations per paper)

Rank	Name	Paper	Journal	Citations
1	P.M. Ridker, et al.	“C-reactive protein levels and outcomes after statin therapy”	New England Journal of Med.	124
2	G.H. Bardy, et al.	“Amiodarone or an implantable cardioverter-defribrillator for congestive heart failure”	New England Journal of Med.	107
3	S.D. Solomon, et al.	“Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention”	New England Journal of Med.	97
4	R.S. Bresalier, et al.	“Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial”	New England Journal of Med.	93
5	J.C. Barrett, et al.	“Haploview: analysis and visualization of LD and haplotype maps”	Bioinformatics	90
6	S.E. Nissen, et al.	“Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease”	New England Journal of Med.	82
7	D.A. Hinds, et al.	“Whole-genome patterns of common DNA variation in three human populations”	Science	74
8	L.P. Lim, et al.	“Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs”	Nature	73
9	E.R. Miller, et al.	“Meta-analysis: High dosage vitamin E supplementation may increase all-cause mortality”	Annals of Internal Medicine	73
10	A. Howell, et al.	“Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years’ adjuvant treatment for breast cancer”	Lancet	69

By far, the field of medicine received the most attention in 2005, with 21 of the top-40 “Hottest Papers” appearing in medicine-focused publications. The two publications that appear most frequently on the list, NEJM and the Lancet, both fall into this category. Multidisciplinary publications (including Science and Nature, which appear third and fourth on the list, respectively), accounted for 10 of the papers included in the rankings.

Journal subject categories:
(Ordered by number of Red-Hot Research Papers in the field)

Subject category	Number of “Red-Hot” Papers
Medicine Multidisciplinary Biochemistry & Molecular Biology Physics Astronomy Computer Science Oncology	21 10 4 2 1 1 1

Journals:
(Ordered by number of Red-Hot Research Papers published in the journal)

Publication	Number of “Red-Hot” Papers
New England Journal of Medicine Lancet Science Nature Nucleic Acids Research Physics Review Letter Annals of Internal Medicine Astronomy Journal Bioinformatics Cancer Cell Cell Journal of the Natn’l Cancer Institute Nature Materials	13 6 5 4 3 2 1 1 1 1 1 1 1

The Science Watch rankings are part of the publication’s annual rankings of the hottest researchers and papers of the year. For the rankings, Thomson Scientific evaluated the number of citations each paper received as indexed in its Web of Science® database (as of late December 2005). All of the papers listed in the rankings were published in 2005.
To learn about Science Watch’s “Hottest Researchers of 2004-2005” or for more information about the hottest research papers, contact Rodney Yancey at 215-823-5397 or rodney.yancey@thomson.com.

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